ÒÀÎÖÎ÷µ¥¿¹£¨Ivonescimab£¬AK112£©ÊÇÒ»¿îÓÉÖйú×ÔÖ÷Ñз¢µÄÈ«ÇòÊ×´´PD-1/VEGFË«ÌØÒìÐÔ¿¹Ì壬ÆäÁ¢Òì»úÖÆÍ¨¹ýͬʱ×è¶ÏPD-1ÓëPD-L1/L2µÄÍŽἰÒÖÖÆVEGFÓëÊÜÌåµÄÏ໥×÷Óã¬ÊµÏÖÖ×ÁöÃâÒßÓ뿹Ѫ¹ÜÌìÉúµÄÐͬЧӦ¡£¸ÃÒ©ÎïΪ·Î°©ÖÎÁÆÌṩÁËеÄÕ½ÂÔ£¬ÓÈÆäÔÚÁÛ×´·ÇСϸ°û·Î°©£¨sqNSCLC£©ÁìÓòÕ¹ÏÖ³öÏÔÖøÇ±Á¦¡£
¡¡¡¡½üÆÚÐû²¼µÄHARMONi-6Ñо¿£¨AK112-306£©ÊÇÒ»ÏîIIIÆÚÁÙ´²ÊÔÑ飬ּÔÚÆÀ¹ÀÒÀÎÖÎ÷µ¥¿¹ÍŽữÁƱÈÕÕÌæÀ×ÀûÖéµ¥¿¹ÍŽữÁÆ×÷ΪÍíÆÚsqNSCLCÒ»ÏßÖÎÁƵÄÁÆÐ§ÓëÇå¾²ÐÔ¡£
¡¡¡¡Ñо¿¹²ÄÉÈë532Àý»¼Õߣ¬ÆäÖÐÔ¼63%ΪÖÐÐÄÐÍÁÛ°©£¬ÓëÕæÊµÌìÏ»¼ÕßÂþÑÜÒ»Ö¡£ÖÐÆÚÆÊÎöÏÔʾ£¬ÔÚÒâÏòÖÎÁÆ£¨ITT£©ÈËȺÖУ¬ÒÀÎÖÎ÷µ¥¿¹ÍŽữÁƵÄÎÞÏ£ÍûÉúÑÄÆÚ£¨PFS£©ÏÔÖøÓÅÓÚÌæÀ×ÀûÖéµ¥¿¹×飨11.1¸öÔÂvs 6.9¸öÔ£©£¬ÇÒÔÚ²î±ðÑÇ×éÖУ¬ÒÀÎÖÎ÷ÍŽữÁƾùÌåÏÖ³öÏÔÖø»ñÒæ£¬°üÀ¨PD-L1±í´ïˮƽ¡¢¸Î×ªÒÆÇéÐμ°»ùÏß×ªÒÆ²¿Î»ÊýÄ¿µÈ¡£Çå¾²ÐÔ·½Ã棬ÒÀÎÖÎ÷µ¥¿¹Î´·ºÆðеÄÇå¾²Ðźţ¬ÓÈÆäÔÚÖÐÐÄÐÍÁÛ°©»¼ÕßÖÐÄÍÊÜÐÔÓÅÒ죬͹ÏÔÆäÍ»ÆÆ¹Å°å¿¹Ñª¹ÜÌìÉúÒ©Îï¾ÖÏÞÐÔµÄDZÁ¦¡£
¡¡¡¡´Ëǰ£¬ÒÀÎÖÎ÷µ¥¿¹µÄÁÆÐ§ÒÑÔÚHARMONi-2ÁÙ´²ÊÔÑ飨NCT05499390£©ÖлñµÃÑéÖ¤£¬¸ÃÑо¿Ð§¹û½ÒÏþÓÚ¡¶ÁøÒ¶µ¶¡·¡£
¡¡¡¡Õë¶Ôδ¾ÖÎÁƵľֲ¿ÍíÆÚ»ò×ªÒÆÐÔPD-L1ÑôÐÔ¡¢EGFR/ALKÒõÐÔ·ÇСϸ°û·Î°©£¨NSCLC£©»¼Õߣ¬ÒÀÎÖÎ÷µ¥¿¹×éÖÐλPFS´ï11.1¸öÔ£¬½ÏÅÁ²©ÀûÖéµ¥¿¹×éµÄ5.8¸öÔÂÑÓÉì5.3¸öÔ¡£
¡¡¡¡ 
¡¡¡¡Á½ÏîIIIÆÚÑо¿µÄÆð¾¢Ð§¹ûÅäºÏÖ§³ÖÒÀÎÖÎ÷µ¥¿¹ÔÚ·ÇСϸ°û·Î°©ÖÎÁÆÖеÄÁÙ´²¼ÛÖµ£¬ÓÈÆäΪδ¾ÖÎÁƵÄÍíÆÚ·ÎÁÛ°©»¼ÕßÌṩÁËеÄÖÎÁÆÑ¡Ôñ¡£
¡¡¡¡²Î¿¼ÎÄÏ×
¡¡¡¡1¡¢Xiong A,Wang L,Chen J,et al.Ivonescimab versus pembrolizumab for PD-L1-positive non-small cell lung cancer(HARMONi-2):a randomised,double-blind,phase 3 study in China.Lancet.2025 Mar 8;405(10481):839-849.doi:10.1016/S0140-6736(24)02722-3.
¡¡¡¡2¡¢Zhiwei Chen,Fang Yang,et al.Ivonescimab plus chemotherapy versus tislelizumab plus chemotherapy as first-line treatment for advanced squamous non-small-cell lung cancer(HARMONi-6):a randomised,double-blind,phase 3 trial.Lancet.2025 Oct 19:S0140-6736(25)01848-3.doi:10.1016/S0140-6736(25)01848-3













































ÔÁ¹«Íø°²±¸ 44030602000441ºÅ 